Case 1: Dr. Jang presented 72M with recurrent high-risk prostate cancer: PSMA+ nodes, rapid PSA rise; biopsy confirmed disease, enrolled in trial after ADT vs MDT debate. Case 2: Dr. Srinivas presented 67M with high-risk prostate cancer: PSMA+ node, Gleason 4+3; chose radiation + 18 mo ADT; panel debated surgery, PET role, and genomics. Case 3: Dr. Maughan presented an advanced prostate cancer case: BRCA2 VUS, TP53 mutation; treated with chemo+PARP, achieved CR but developed MDS; panel stressed biopsy and cautious sequencing. Case 4: Dr. Vaishampayan presented a metastatic prostate cancer case: liver mets, PTEN loss; initial ADT/ARPI response, later progression; Pluvicto led to CR and undetectable PSA.